The Effect of Chromium and Boron on the Lipid Peroxidation and Antioxidant Status (in Experiment)
Abstract
Current anthropogenic factors have a destructive effect on the environment. In this connection, it becomes necessary to study the negative effects of substances on living organisms and ways to reduce them. This article evaluated the impact of potassium dichromate (K2Cr2O7) and boric acid (H3BO3) on the status of lipid peroxidation (LPO) and antioxidant system.
The work is performed on 24 male rats of Wistar weighing 180-220 g, were grown in the vivarium of the Central research laboratory of West Kazakhstan state medical University named after Ospanov.
An experiment on Wistar rats: 1st - warning; 2nd - received K2Cr2O7; 3rd – H3BO3; 4th – K2Cr2O7 and H3BO. The introduction of K2Cr2O7 intensified LPO and reduced activity of catalase, glutathione peroxidase and superoxide dismutase, the number of sulfhydryl groups. The results of the study allow asserting that the H3BO3 in the conditions of joint use with K2Cr2O7 has an antioxidant effect, which leads to inhibition of LPO and activation of antioxidant system. Therefore, we first established the antioxidant effect of boric acid in the combined effects of potassium dichromate and boric acid.
References
References
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[12] Khanna, S, Raffals, L.E. 2017. The Microbiome in Crohn's Disease: Role in Pathogenesis and Role of Microbiome Replacement Therapies. Gastroenterology Clinics of North America. DOI: http://dx.doi.org/10.1016/j.gtc.2017.05.004
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[24] Zamaraev, A.V, Kopeina, G.S, Prokhorova, E.A, Zhivotovsky, B, Lavrik, I.N. 2017. Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. Trends in Cell Biology. DOI http://dx.doi.org/10.1016/j.tcb.2017.01.003
*** Strasburg: Council of Europe. 1986. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, 48 p.
[1] Abbas, S.R, Sabir, S.M, Ahmad S.D, Boligon A.A, Athayde, M.L. 2014. Phenolic profile, antioxidant potential and DNA damage protecting activity of sugarcane (Saccharum officinarum). Food chemistry 147: 10-16.
[2] Ahangarpour, A, Oroojan, A.A, Rezaei, M, Khodayar, M.J, Alboghobeish, S, Zeinvand, M. 2017. Effects of butyric acid and arsenic on isolated liver mitochondria and pancreatic islets of male mouse. Gastroenterology and Hepatology from bed to bench, Winter; 10(1): 44–53.
[3] Cang, S, Xu, X, Ma, Y, Liu, D, Chiao, J.W. 2016. Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells. Journal of Hematology & Oncology 9(1): 3.
[4] Canturk, Z, Tunali, Y, Korkmaz, S, Gulbaş, Z. 2016. Cytotoxic and apoptotic effects of boron compounds on leukemia cell line. Cytotechnology 68(1): 87-93.
[5] Gentile, F, Arcaro, A, Pizzimenti, S, Daga, M, Cetrangolo, G.P, Dianzani, C, Barrera, G. 2017. DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity. AIMS Genetics 4(2): 103-137.
[6] Guertin, J, Jacobs, J.A, Avakian, C.P. (Eds.). 2016. Chromium (VI) handbook. CRC press. ISBN: 0203487966, 9780203487969, 800 p.
[7] He, J.H, Gao, J.M, Huang, C.J, Li, C.Q. 2014. Zebrafish models for assessing developmental and reproductive toxicity. Neurotoxicology and teratology 42: 35-42.
[8] Ince, S, Kucukkurt, I, Demirel, H.H, Acaroz, D.A, Akbel, E, Cigerci, I.H. 2014. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere 108: 197-204.
[9] Iztleuov, M, Umirzakova, Z, Iztleuov, E, Sambaeva, S, Iztleuova, G, Yesmukhanova, D, Kolishbaeva, I. 2017. The Effect of Chromium and Boron on the Lipid Peroxidation and Antioxidant Status (In Experiment). BioTechnology: An Indian Journal 13(1).
[10] Jaishankar, M, Tseten, T, Anbalagan, N, Mathew, B.B, Beeregowda, K.N. 2014. Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary toxicology 7(2): 60-72.
[11] Judah, L, Marin, R, Stroup, D, Wesdemiotis, C, Bose, R.N. 2014. DNA damage by oxo-and peroxo-chromium (v) complexes: Insight into the mutation and carcinogenesis mechanisms. Toxicology Research 3(1): 56-66.
[12] Khanna, S, Raffals, L.E. 2017. The Microbiome in Crohn's Disease: Role in Pathogenesis and Role of Microbiome Replacement Therapies. Gastroenterology Clinics of North America. DOI: http://dx.doi.org/10.1016/j.gtc.2017.05.004
[13] Kolgelier, S, Ergin, M, Demir, L.S, Inkaya, A.C, Demir, N.A, Alisik, M, Erel, O. 2017. Impaired Thiol-Disulfide Balance in Acute Brucellosis. Japanese Journal of Infectious Diseases 70(3): 258-262.
[14] Lai, P.L, Chen, W.C, Wang, J.C, Fu, P.S, Lin, C.C, Hung, C.C. 2017. The possibility of recasting of pure titanium. Journal of Dental Sciences. DOI: http://dx.doi.org/10.1016/j.jds.2017.02.004
[15] Li, W.J, Yang, C.L, Chow, K.C, Kuo, T.W. 2016. Hexavalent chromium induces expression of mesenchymal and stem cell markers in renal epithelial cells. Molecular Carcinogenesis 55(2): 182-192.
[16] Lopez-Cruzan, M, Sharma, R, Tiwari, M, Karbach, S, Holstein, D, Martin, CR, Herman, B. 2016. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discovery 2: 16005.
[17] Luanpitpong, S, Chanvorachote, P, Stehlik, C, Tse, W, Callery, P.S, Wang, L, Rojanasakul, Y. 2013. Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells. Molecular Biology of the Cell 24(6): 858-869.
[18] Park, K.A, Choi, Y.M, Kang, S, Kim, M.R, Hong, J. 2015. Effects of Proteins on the Reactivity of Various Phenolic Compounds with the Folin-Ciocalteu Reagent. Korean Journal of Food Science and Technology 47(3): 299-305.
[19] Park, S, Li, C, Zhao, H, Darzynkiewicz, Z, Xu, D. 2016. Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells. Oncotarget 7(8): 8916.
[20] Sabirova, E.G, Sarbaeva, E.V. 2016. Prospects of Application of Technologies of Test Control of Students’ Knowledge in the Direction of Preparation «Ecology and Environmental Management». IEJME-Mathematics Education 11(6): 1723-1734.
[21] Wang, X, Son, Y.O, Chang, Q, Sun, L, Hitron, J.A, Budhraja, A, Zhang, Z, Ke, Z, Chen, F, Luo, J, Shi, X. 2011. NADPH Oxidase Activation Is Required in Reactive Oxygen Species Generation and Cell Trasformation Induced by Hexavalent Chromium. Toxicological Sciences 123(2): 399-410.
[22] Watabe, T, Hanaoka, K, Naka, S, Kanai, Y, Ikeda, H, Aoki, M, Hatazawa, J. 2017. Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET. Annals of Nuclear Medicine 1-5.
[23] Wise, S.S, Wise, J.P. 2012. Chromium and genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 733(1): 78-82.
[24] Zamaraev, A.V, Kopeina, G.S, Prokhorova, E.A, Zhivotovsky, B, Lavrik, I.N. 2017. Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. Trends in Cell Biology. DOI http://dx.doi.org/10.1016/j.tcb.2017.01.003
*** Strasburg: Council of Europe. 1986. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, 48 p.
Published
2017-09-25
How to Cite
IZTLEUOV, Marat et al.
The Effect of Chromium and Boron on the Lipid Peroxidation and Antioxidant Status (in Experiment).
Journal of Environmental Management and Tourism, [S.l.], v. 8, n. 3, p. 529-536, sep. 2017.
ISSN 2068-7729.
Available at: <https://journals.aserspublishing.eu/jemt/article/view/1379>. Date accessed: 15 nov. 2024.
doi: https://doi.org/10.14505//jemt.v8.3(19).04.
Section
Article
Copyright© 2024 The Author(s). Published by ASERS Publishing 2024. This is an open access article distributed under the terms of CC-BY 4.0 license.